Song Chen 

Who's Song?

Key areas of expertise:  

MY BACKGROUND

Self-motivated cancer biologist, tumor immunologist, and code developer with a background in biotechnology and engineering and extensive experience in human breast cancer cell migration and in vivo immune cell trafficking.Especially effective in inter-disciplinary teams as demonstrated by extensive collaboration with clinicians, chemists, and engineers. Current projects focus on the chemokine systems on T lymphocytes during immunotherapy.

• Breast cancer biology

• Tumor immunology 

• Cell migration 

• Intracellular signaling 

• Murine tumor models

•  Flow cytometry

• Confocal microscopy 

• Image processing & analysis 

• Program development 

• Experiment design

Massachusetts General Hospital    

Education

WHAT I’VE LEARNED

2017– 2020 

University of Michigan – Ann Arbor, MI

PhD, Pharmacology, transferred from UMD 

GPA: 3.92/4.00

2014– 2017

University of Maryland – College Park, MD

PhD, Biophysics, GPA: 3.95/4.00

2011– 2014

Fudan University – Shanghai, China 

MS, Condensed Matter Physics 

2007– 2011

East China University of Science and Technology – Shanghai, China 

BS, Applied physics 

Experience

WHERE I’VE WORKED

Feb. 2020– Present

Massachusetts General Hospital – Boston, MA

Research Fellow

July. 2017– Dec. 2020 

Projects &

Publications 

The role of CCR8 chemokine system in Treg-mediated tumor resistance to immune checkpoint blockade

Regulatory T cells (Tregs) are a subset of CD4+ T cells that are responsible to maintain the periphery tolerance and keep the immune response “in check”. However, just like two sides of a coin, the presence of Tregs in the tumor microenvironment can dampen the anti-tumor immunity and promote tumor progression...... 

Collective Migration of Keratinocytes during Wound Healing 

Wound healing is a complex process in which the migration of keratinocytes play a key role. Upon injury, surviving wound-proximal keratinocytes  suspend terminal differentiation and undergo dramatic changes to prepare for migration......

Contact Guidance during Breast Cancer Cell Metastasis

Cancer invasion and metastasis are major life threatening events in cancer patients.Physical guidance from the underlying matrix is a key regulator of cancer invasion and metastasis. We explore the effects of surface topography on the migration phenotype of multiple breast cancer cell lines...... 

Adenylyl Cyclase A mRNA Localization during Dictyostelium Chemotaxis

Chemotaxis, the ability of cells to migrate towards chemical gradients, is fundamental to various biological and pathological processes. It is also essential for the lifecycle of Dictyostelium cells ......

Skills & Languages  

WHAT I BRING TO THE TABLE

Molecular and cellular biology 

Microscopy 

Image processing & analysis 

In vivo tumor models

Multiplexing flow cytometry

Literature searching & evaluation 

Academic writing 

English 

Chinese 

Awards

WHERE I SHINE

Lucchesi Predoctoral Fellowship Award 

2019     University of Michigan 

First Prize in Image Competition                    

2018     CellulART Conference, University of Toledo 

Fellowship Support, NCI/UMD Partnership for Integrative Cancer Research                    

2015 – 2017     National Cancer Institute and University of Maryland

Dean's Fellowship                     

2014     University of Maryland

Shanghai Outstanding Graduate Student       2014     Fudan University 

Interests

OUT OF OFFICE

Cooking

Travel & Road trip & Photography