Feb. 2020– Present
Massachusetts General Hospital – Boston, MA
Design and execute in vivo experiments to understand the functional role of chemokine systems in guiding cytotoxic T lymphocytes to tumors and their subsequent activation during immunotherapy. The current project also aims to elucidate how chemokines and their receptors on regulatory T cells contribute to tumor resistance to immune checkpoint blockade therapy.
Graduate Student Researcher
July. 2017– Present
University of Michigan – Ann Arbor, MI
The primary responsibility includes efficient execution of experiments and completion of the project goals which are:
1. Elucidation of mechanisms of contact guidance in cancer metastasis
2. The role of intrinsic mutations and cell-topography contact of cancer cells in contact guidance
3. Illustration of mechanisms of exosome biogenesis in neutrophils
Other responsibilities include search and evaluate existing literature, design of experiments,interpretation and analysis of the data hence obtained, compiling results, and communicating publications.
Jun. 2015– July. 2017
National Cancer Institute – Bethesda, MI
1. Design and execution of a series of experiments with human breast cancer cells on bio-inspired nanotopographies.
2. Conducted experiments and developed a novel, systematic quantification method in MATLAB to understand the role of asymmetrically localized adenylyl cyclase A (ACA) mRNA in Dictyostelium chemotaxis. This work was in collaboration with a postdoctoral fellow in our group and led to a publication in the Journal of Cell Science.
3. Adapted particle image velocimetry (PIV) method to quantify the collective migration of keratinocytes to uncover the mechanisms by which keratin 6 regulates the collective keratinocyte migration during wound healing. This work was in collaboration with a graduate student from Dr. Pierre Coulombe's lab at Johns Hopkins University and led to a publication in the Journal of Cell Biology.
4. Present scientific work at national and international conferences.
Sep. 2014– July. 2017
University of Maryland – College park , MD
Fabricated bio-inspired nanotopographies in collaboration with graduate students from Dr. JohnFourkas's group at University of Maryland
Graduate Student Researcher
Sep. 2011– Jun. 2014
Fudan University – Shanghai, China
1. Designed computer-controlling automatic sample stage system to record multiple cell samples simultaneously.
2. Conducted series of experiments of random Dictyostelium cell migration, analyzed obtained data and compiled results for a publication in Soft Matter.
3. Assisted other colleagues in our group with the execution of their experiments and interpretation of the results resulting several publications.